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Nutrigenomics and pharmacogenomics: a scientific wonderland

Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA and Salugen, Inc., San Diego, CA, USA, Drd2gene{at}aol.com

Thomas J.H. Chen

Chang Jung Christian University, Republic of China and Chang Hua Christian Hospital, Republic of China

Seth H. Blum

Synaptamine Inc., 3707 Castle Crest, San Antonio, TX, 78230, USA, gosethgo{at}msn.com

Bernard W. Downs

Allied Nutraceutical Research, Lederach, PA, P.O. Box 366, Lederach, PA 19450, USA, bdowns{at}alliednutraceutical.com

Eric R. Braverman

Path Medical Research Foundation, 185 Madison Ave, New York, NY 10019, USA, pathmedical{at}aol.com

Julie F. Mengucci

Synaptamine Inc., 3707 Castle Crest, San Antonio, TX, 78230, USA, gosethgo{at}msn.com

Brian Meshkin

Salugen, Inc., San Diego, 4660 La Jolla Village Drive Suite 500, San Diego, CA 92122, USA, bmeshkin{at}salugen.com

English

As scientists engaged in understanding the potential of drug/nutrient responses as a function of our genome and all of its ramifications including academic and commercial aspects, our future looks bright. While, however, being cautious about our future especially in terms of regulatory issues, gene-nutrition interactions especially related to genome-based response will indeed be the next cornerstone of solid scientific approaches to assist individuals in choosing dietary supplements, functional foods, and even nutritional beverages on an individualized basis. Nutrigenomics is the key to what we have termed "nutritional gene therapy" and from its origin will spring gene mapping as the wave of the future in nutrition. The information provided in this article will serve as evidence of our conviction of this scientific wonderland of opportunity (see Daniel, 2002).

French

Dès lors que les scientifiques ont commencé à s'intéresser aux réactions potentielles aux médicaments/aliments en fonction de notre génome ainsi qu'à tous leurs aspects, y compris académiques et commerciaux, notre futur s'éclaire. Tout en restant prudent à l'avenir, en particulier en termes de problèmes de régulation, il est clair que les interactions gènes-nutrition, en particulier celles liées aux réactions en fonction du génome, seront la pierre angulaire d'approches scientifiques solides, qui guideront les individus dans le choix de suppléments nutritionnels, d'une alimentation fonctionnelle, et même de boissons nutritionnelles, de façon individualisée. La "Nutrigénomique'' est la clé de ce que nous appelons la "thérapie génique nutritionnelle'' et placera d'emblée la carte génique au coeur de l'avenir de la nutrition. Cet article présente des données propres à étayer notre conviction de ce "pays des merveilles'' scientifique qui se trouve à notre portée (Daniel, 2002).

Key Words: Drug/nutrient response • Gene mapping • Gene-nutrition interaction • Genome-based response • Nutrigenomics

Social Science Information, Vol. 45, No. 1, 35-52 (2006)
DOI: 10.1177/0539018406061102


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